V2 Vasopressin R/AVPR2: Small Molecules and Peptides
AVPR2 is the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes AVPR2 is well conserved, though several members signal via other G proteins. AVPR2 is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results.
4 results for "V2 Vasopressin R/AVPR2 Small Molecules and Peptides" in Products
4 results for "V2 Vasopressin R/AVPR2 Small Molecules and Peptides" in Products
V2 Vasopressin R/AVPR2: Small Molecules and Peptides
AVPR2 is the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes AVPR2 is well conserved, though several members signal via other G proteins. AVPR2 is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results.
Synthetic vasopressin analog; V1B and V2 agonist
| Purity: | ≥95% (HPLC) |
Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable
| Chemical Name: | N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active
| Alternate Names: | OPC-41061 |
| Chemical Name: | N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide |
| Purity: | ≥98% (HPLC) |
Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist
| Chemical Name: | (2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide |
| Purity: | ≥97% (HPLC) |
