USP25: Small Molecules and Peptides

Ubiquitin Specific Peptidase 25 (USP25) is a cytoplasmic protein that belongs to the peptidase C19 family of deubiquitinating enzymes. It has been shown to be expressed as three tissue-specific isoforms: USP25a, USP25b, and USP25m. The canonical isoform, USP25a, is 1055 amino acids (aa) in length and has a predicted molecular weight of 122.2 kDa. Human USP25a shares 94% aa sequence identity with the mouse and rat orthologs. It is widely expressed with the highest levels being observed in fetal ...