7 results for "Smoothened Receptor Antagonists" in Products
Smoothened Receptor Antagonists Products
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to and repressed by patched (Ptc).
Upon Hh-Ptc interaction, Smo receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the activity of transcription factors belonging to the Gli family ...
Potent Smoothened receptor antagonist
| Chemical Name: | rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide |
| Purity: | ≥98% (HPLC) |
Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity
| Chemical Name: | N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine |
| Purity: | ≥98% (HPLC) |
High affinity and selective Smoothened (Smo) receptor antagonist
| Chemical Name: | 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride |
| Purity: | ≥98% (HPLC) |
Inhibitor of Hedgehog (Hh) signaling
| Chemical Name: | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol |
| Purity: | ≥97% (HPLC) |
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)
| Chemical Name: | 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one |
| Purity: | ≥98% (HPLC) |
Potent Smo antagonist
| Chemical Name: | N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide] |
| Purity: | ≥98% (HPLC) |
Potent Smo antagonist
| Alternate Names: | glasdegib,PF-913 |
| Chemical Name: | 1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt |
| Purity: | ≥98% (HPLC) |
