SMAC/Diablo Products
SMAC (second mitochondria-derived activator of caspase)/Diablo, the mammalian functional homologue of Drosophila Hid, Grim, and Reaper, regulates apoptosis by neutralizing inhibitor of apoptosis (IAP) proteins. IAP family members contain one to three baculovirus IAP repeat (BIR) domains, each exhibiting distinct functions and caspase specificity. The BIR2 domain inhibits caspase-3 and –7, whereas the BIR3 domain inhibits caspase-9 activity. SMAC/Diablo interacts with BIR2 and BIR3 domains of IAPs, thereby neutralizing IAP inhibition and promoting caspase catalytic activity and apoptosis.
112 results for "SMAC/Diablo" in Products
112 results for "SMAC/Diablo" in Products
SMAC/Diablo Products
SMAC (second mitochondria-derived activator of caspase)/Diablo, the mammalian functional homologue of Drosophila Hid, Grim, and Reaper, regulates apoptosis by neutralizing inhibitor of apoptosis (IAP) proteins. IAP family members contain one to three baculovirus IAP repeat (BIR) domains, each exhibiting distinct functions and caspase specificity. The BIR2 domain inhibits caspase-3 and –7, whereas the BIR3 domain inhibits caspase-9 activity. SMAC/Diablo interacts with BIR2 and BIR3 domains of IAPs, thereby neutralizing IAP inhibition and promoting caspase catalytic activity and apoptosis.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: SMAC/Diablo Antibody [NB100-56311]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-Western-Blot-NB100-56311-img0006.jpg "Western Blot: SMAC/Diablo Antibody [NB100-56311]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #78-1-118 |
| Applications: | WB, ICC/IF, IP |
![Western Blot: SMAC/Diablo Antibody (78-1-118) [NB500-213]](https://resources.bio-techne.com/images/products/Smac-Antibody-78-1-118-Western-Blot-NB500-213-img0002.jpg "Western Blot: SMAC/Diablo Antibody (78-1-118) [NB500-213]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP, Simple Western |
![Western Blot: SMAC/Diablo Antibody [NB100-56165]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-Western-Blot-NB100-56165-img0003.jpg "Western Blot: SMAC/Diablo Antibody [NB100-56165]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Source: | E. coli |
| Accession #: | Q9NR28 |
| Applications: | InhibAct |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |
![Western Blot: SMAC/Diablo Antibody (006) [NBP2-89251]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-006-Western-Blot-NBP2-89251-img0001.jpg "Western Blot: SMAC/Diablo Antibody (006) [NBP2-89251]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunohistochemistry-Paraffin: SMAC/Diablo Antibody [NBP1-84262]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-Immunohistochemistry-Paraffin-NBP1-84262-img0009.jpg "Immunohistochemistry-Paraffin: SMAC/Diablo Antibody [NBP1-84262]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S08-6A3 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: SMAC/Diablo Antibody (S08-6A3) [NBP3-19775]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-S08-6A3-Western-Blot-NBP3-19775-img0003.jpg "Western Blot: SMAC/Diablo Antibody (S08-6A3) [NBP3-19775]")