SHP-2 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
173 results for "SHP-2" in Products
173 results for "SHP-2" in Products
SHP-2 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
Protein tyrosine phosphatase inhibitor
| Chemical Name: | Trisodium vanadate |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Simple Western, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #255509 |
| Applications: | WB, KO |
| Source: | E. coli |
| Accession #: | NP_002825.3 |
| Applications: | EnzAct |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #255509 |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, KO |
![Western Blot: SHP-2/PTPN11 Antibody [NBP1-33064]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-Western-Blot-NBP1-33064-img0012.jpg "Western Blot: SHP-2/PTPN11 Antibody [NBP1-33064]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #6D9 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
![Western Blot: SHP-2/PTPN11 Antibody (6D9)BSA Free [NBP2-37454]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-6D9-Western-Blot-NBP2-37454-img0002.jpg "Western Blot: SHP-2/PTPN11 Antibody (6D9)BSA Free [NBP2-37454]")
Substrate for PTP1B, TC-PTP, SHP-2, and Tyrosine Phosphatase
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #255509 |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #255509 |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |