NTS2/NTSR2: Small Molecules and Peptides
Binding and pharmacological studies demonstrate that NTSR2 binds neurotensin as well as several other ligands already described for NTSR1. Unlike NTSR1, NTSR2 recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. NTSR2 may be of physiological importance and a natural agonist for the receptor may exist.
2 results for "NTS2/NTSR2 Small Molecules and Peptides" in Products
2 results for "NTS2/NTSR2 Small Molecules and Peptides" in Products
NTS2/NTSR2: Small Molecules and Peptides
Binding and pharmacological studies demonstrate that NTSR2 binds neurotensin as well as several other ligands already described for NTSR1. Unlike NTSR1, NTSR2 recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. NTSR2 may be of physiological importance and a natural agonist for the receptor may exist.
Potent and selective non-peptide NTS2 antagonist
| Chemical Name: | N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine |
| Purity: | ≥98% (HPLC) |
Highly potent NTS receptor antagonist
| Chemical Name: | 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid |
| Purity: | ≥97% (HPLC) |
