Integrin alpha 2/CD49b: Proteins and Enzymes

Integrin alpha 2 is one of twelve Integrin alpha subunits that associates with the beta 1 subunit. Integrin alpha 2 beta 1 (VLA-2) is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is one of six very late antigens expressed on activated T cells. Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended, and open conformation. a2b1 binds to Collagen types I, II, and III, Laminin, Decorin, E‑Cadherin, and Collectin ...