Galectin-9: Proteins and Enzymes

Galectin-9 is a secreted carbohydrate-binding protein with two lectin domains connected by a linker region. Progressive deletion within the linker region generates an isoform known as Ecalectin or UAT. Galectin-9 binds to carbohydrate moieties of IgE, preventing immune complex formation, mast cell degranulation, and asthmatic and cutaneous anaphylaxis reactions. It functions as an eosinophil chemoattractant and induces the maturation of dendritic cells which promote Th1 polarization. Galectin-9 ...