FGFR3: Proteins and Enzymes

FGFR3 (fibroblast growth factor receptor 3), also known as CEK2 and CD333, is a transmembrane receptor tyrosine kinase that plays a role in skeletal development and tumorigenesis. Alternative splicing generates beta isoforms of the receptor which lack the first Ig-like domain as well as IIIb isoforms that have a substitution in the third Ig-like domain. FGFR3 (IIIb) triggers cell proliferation in response to FGF acidic and FGF-9, while FGFR3 (IIIc) shows a wider selectivity that includes FGF ...