Ephrin-A4: Proteins and Enzymes

There are two structural groups of ephrin ligands which bind to a family of receptor tyrosine kinases (Eph). A-type ephrins bind A-type receptors, which are tethered to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. B-type ephrins bind to B-type receptors, which have a single transmembrane domain and a cytoplasmic region. All ephrin ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence ...