Endothelin-1 Products
Endothelin-1 (ET-1) is a vascular endothelium derived peptide that acts as a potent vasoconstrictor. It is processed by a furin-like protease to yield a peptide termed Big ET-1. Big ET-1 is then cleaved by ECE-1, producing the mature form ET-1 (1-21). ET-1 expression is induced by mechanical stimulation, various hormones, and pro-inflammatory cytokines. Its production is inhibited by nitric oxide, prostacyclin, and atrial natriuretic peptide (ANP). ET-1 exerts its vasoconstrictor effects primarily through the receptor ETA on vascular smooth muscle cells. It also acts through the ETB receptor on vascular smooth muscle and endothelial cells. ET-1 additionally stimulates cardiac myocyte proliferation and contractility, regulates secretion by hypothalamic and pituitary cells, and promotes neutrophil extravasation and activation.
154 results for "Endothelin-1" in Products
154 results for "Endothelin-1" in Products
Endothelin-1 Products
Endothelin-1 (ET-1) is a vascular endothelium derived peptide that acts as a potent vasoconstrictor. It is processed by a furin-like protease to yield a peptide termed Big ET-1. Big ET-1 is then cleaved by ECE-1, producing the mature form ET-1 (1-21). ET-1 expression is induced by mechanical stimulation, various hormones, and pro-inflammatory cytokines. Its production is inhibited by nitric oxide, prostacyclin, and atrial natriuretic peptide (ANP). ET-1 exerts its vasoconstrictor effects primarily through the receptor ETA on vascular smooth muscle cells. It also acts through the ETB receptor on vascular smooth muscle and endothelial cells. ET-1 additionally stimulates cardiac myocyte proliferation and contractility, regulates secretion by hypothalamic and pituitary cells, and promotes neutrophil extravasation and activation.
| Sensitivity: | 0.207 pg/mL |
| Applications: | ELISA |
| Assay Range: | 0.39 - 25 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Sensitivity: | 0.102 pg/mL |
| Applications: | ELISA |
| Assay Range: | 0.34 - 250 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Urine) |
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
| Alternate Names: | ET-1 |
| Purity: | ≥95% (HPLC) |
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Applications: | Ctrl, Simple Plex |
| Assay Range: | 3.91 - 250 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #3G10 |
| Applications: | ELISA, ICC |
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #3G10 |
| Applications: | ELISA, ICC |
| Applications: | Ctrl |
| Applications: | ELISA, Ctrl |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2E1 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1065402 |
| Applications: | ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2E1 |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #3D6 |
| Applications: | WB, ELISA, ICC/IF, IP |
![Western Blot: Endothelin-1 Antibody (3D6) [H00001906-M01]](https://resources.bio-techne.com/images/products/Endothelin-1-Antibody-3D6-Western-Blot-H00001906-M01-img0005.jpg "Western Blot: Endothelin-1 Antibody (3D6) [H00001906-M01]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2E1 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2E1 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #3G10 |
| Applications: | ELISA, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1065402 |
| Applications: | ICC |
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #3G10 |
| Applications: | ELISA, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2E1 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #3G10 |
| Applications: | ELISA, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1065402 |
| Applications: | ICC |
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #3G10 |
| Applications: | ELISA, ICC |