CXCR4 Products

CXCR4, also known as fusin or LESTR, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR4 is 352 amino acids (aa) in length with a predicted molecular weight of 40 kDa. The mouse and rat proteins share 91% aa sequence identity with the human protein. CXCR4 is the chemokine receptor for CXCL12. CXCR4 is a critical regulator of progenitor and stem cell mobilization and recruitment during development and during hematopoiesis. As such, antagonists ...