Cathepsin C/DPPI: Proteins and Enzymes

Cathepsin C is a papain family cysteine protease that sequentially removes dipeptides from the free N-termini of proteins and peptides. It has broad specificity except that it does not cleave a basic amino acid (Arg or Lys) in the N-terminal position or Pro on either side of the scissle bond. The pro form contains a pro peptide and a catalytic region, which can be further processed into heavy/a and light/b chains that are linked by a disulfide bond.