30 results for "BRD2" in Products
BRD2 Products
BRD2 (bromodomain-containing 2) is a nuclear mitogen-activated kinase that plays a role in transcription of cell-cycle-regulated genes (1). Alternate names for BRD2 include RING3, NAT, RNF3, FSRG1, D6S113E, FLJ31942, DKFZp686N0336, and KIAA9001 (2). BRD2 belongs to the BET (bromodomain/extra terminal domain) family of proteins which contain two tandem bromodomains (BDI and BDII) and an extra-terminal (ET) domain (1, 3). In mammals there are four BET paralogs (BRD2, BRD3, BRD4, and BRDT) which ...
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP, Func |
![Western Blot: BRD2 Antibody [NBP1-30475]](https://resources.bio-techne.com/images/products/BRD2-Antibody-Western-Blot-NBP1-30475-img0024.jpg "Western Blot: BRD2 Antibody [NBP1-30475]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Mycoplasma |
![Immunocytochemistry/ Immunofluorescence: BRD2 Antibody [NBP1-84310]](https://resources.bio-techne.com/images/products/BRD2-Antibody-Immunohistochemistry-Paraffin-NBP1-84310-img0014.jpg "Immunocytochemistry/ Immunofluorescence: BRD2 Antibody [NBP1-84310]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF, IP |
![Western Blot: BRD2 Antibody [NBP1-30474]](https://resources.bio-techne.com/images/products/BRD2-Antibody-Western-Blot-NBP1-30474-img0005.jpg "Western Blot: BRD2 Antibody [NBP1-30474]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #3D10 |
| Applications: | WB, ELISA |
![Western Blot: BRD2 Antibody (3D10) [H00006046-M01]](https://resources.bio-techne.com/images/products/BRD2-Antibody-3D10-Western-Blot-H00006046-M01-img0004.jpg "Western Blot: BRD2 Antibody (3D10) [H00006046-M01]")
| Reactivity: | Human, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #7C1B10 |
| Applications: | WB, ELISA, Flow |
![Western Blot: BRD2 Antibody (7C1B10)BSA Free [NBP2-61716]](https://resources.bio-techne.com/images/products/BRD2-Antibody-7C1B10-Western-Blot-NBP2-61716-img0004.jpg "Western Blot: BRD2 Antibody (7C1B10)BSA Free [NBP2-61716]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #BL-167-2A2 |
| Applications: | WB, Flow, IP |
![Western Blot: BRD2 Antibody (BL-167-2A2) [NBP2-76410]](https://resources.bio-techne.com/images/products/BRD2-Antibody-BL-167-2A2-Western-Blot-NBP2-76410-img0004.jpg "Western Blot: BRD2 Antibody (BL-167-2A2) [NBP2-76410]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF, ChIP |
![BRD2 Antibody Immunocytochemistry/Immunofluorescence: BRD2 Antibody [NBP3-25302]](https://resources.bio-techne.com/images/products/nbp3-25302_rabbit-brd2-pab-1912202316102324.jpg "Immunocytochemistry/Immunofluorescence: BRD2 Antibody [NBP3-25302]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #12C2E4 |
| Applications: | WB, IP |
![Immunoprecipitation: BRD2 Antibody (12C2E4) [NBP2-14861]](https://resources.bio-techne.com/images/products/BRD2-Antibody-12C2E4-Immunoprecipitation-NBP2-14861-img0003.jpg "Immunoprecipitation: BRD2 Antibody (12C2E4) [NBP2-14861]")
| Reactivity: | Mouse |
| Details: | Rabbit Polyclonal |
| Applications: | WB, ELISA |
![ELISA: BRD2 Antibody [NBP3-18662]](https://resources.bio-techne.com/images/products/BRD2 "ELISA: BRD2 Antibody [NBP3-18662]")
| Applications: | PAGE |
![SDS-PAGE: Recombinant Human BRD2 His Protein [NBP2-51885]](https://resources.bio-techne.com/images/products/BRD2-Recombinant-Protein-SDS-Page-NBP2-51885-img0001.jpg "SDS-PAGE: Recombinant Human BRD2 His Protein [NBP2-51885]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #5K5Y6 |
| Applications: | WB, ELISA |
| Applications: | WB |
BET bromodomain inhibitor; orally bioavailable
| Alternate Names: | Birabresib |
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% (HPLC) |
Potent and selective BET bromodomain inhibitor; cell permeable
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester |
| Purity: | ≥98% (HPLC) |
Potent molecular glue Degrader of BET proteins BRD4 and BRD2
| Chemical Name: | tert-Butyl 2-((S)-4-(4-((4'-((S)-6-(2-(tert-butoxy)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-[1,1'-biphenyl]-4-carboxamido)methyl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4
| Chemical Name: | (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% (HPLC) |
(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% (HPLC) |
BET bromodomain inhibitor; arrests cell cycle at G1 phase
| Alternate Names: | TEN 010 |
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% (HPLC) |
Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)
| Chemical Name: | N,N'-(11-((2-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide) |
| Purity: | ≥98% (HPLC) |
Negative control for SIM1 (Cat. No. 7432)
| Chemical Name: | N,N'-(11-((2-(((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide) |
| Purity: | ≥98% (HPLC) |
Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells
| Chemical Name: | (2S,4R)-1-((S)-2-(tert-Butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain inhibitor
| Chemical Name: | 1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains |
| Purity: | ≥98% (HPLC) |
