4-1BB/TNFRSF9/CD137 Products
4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.
569 results for "4-1BB/TNFRSF9/CD137" in Products
569 results for "4-1BB/TNFRSF9/CD137" in Products
4-1BB/TNFRSF9/CD137 Products
4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, Flow, IHC, AgAct, +2 More |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, AgAct, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #158321 |
| Applications: | AgAct |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2356B |
| Applications: | WB, Simple Western, Flow, CyTOF-ready, ICC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #145501 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, AgAct, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #158332 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #158306 |
| Applications: | WB, Block |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, AgAct, CyTOF-ready, +3 More |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #158306 |
| Applications: | WB, Block |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #158306 |
| Applications: | WB, Block |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #158306 |
| Applications: | WB, Block |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2356C |
| Applications: | Flow, AgAct, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #145501 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #158332 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2356C |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2356B |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #158332 |
| Applications: | Flow |
| Reactivity: | Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow, CyTOF-ready, ICC |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #158306 |
| Applications: | WB, Block |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #158306 |
| Applications: | WB, Block |