Bio-Techne Spatial

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Advancing Research from Discovery to the Clinic

Bio-Techne Spatial, a global leader in spatial biology, inspires scientists to see biology differently. By making spatial biology solutions accessible, flexible, and actionable, we help uncover insights that drive research from discovery to the clinic. Through collaboration, innovation, and a comprehensive portfolio of trusted tools, we inspire discoveries with real-world impact that transform scientific understanding.

Powered by the gold-standard RNAscope™ RNA ISH Technology and the flagship COMET™ Spatial Biology Platform, we equip researchers with the right solutions to advance science and improve health outcomes.

Spatial Technologies to Enable Your Research

Assess neurogenesis (progenitor stem cells) in mouse brain. Simultaneous detection of a panel of 2 Proteins (NeuN, GFAP) and 4 target RNA (Prox1, Ascl1, Calb2, Top2a) and in FFPE mouse brain hippocampal tissue. Nuclei were stained with DAPI.

Proven RNAscope Technology for RNA and Multiomic Detection

RNAscope from Advanced Cell Diagnostics is the gold standard RNA ISH multiomic technology with patented probe design, enhancing precision and scalability in life science research.
RNAscope can address a variety of applications with versatility and unmatched spatial precision: from single-marker ISH detection to high-plex multiomics (RNA and protein), the user can detect, visualize, and quantify across any RNA target with industry-leading specificity and sensitivity at the single-molecule level and subcellular resolution.
Select from mRNAs, non-coding, splice variants, reporters, transgenes, and more. Utilize over 80,000 catalog probes or create a custom design for any target.

Explore the RNAscope portfolio

ACD HiPlex Pro on COMET image - melanoma

Fully Automated Detection of RNA and Protein with the COMET

COMET from Lunaphore is the only fully-automated, high-throughput, hyperplex platform, enabling dramatic improvement in the understanding of disease pathology.
COMET provides walk-away automation, integrating staining, imaging, and image preprocessing steps to obtain standard hyperplex images, ensuring scalability and reproducibility without the need to conjugate primary antibodies.
The end-to-end spatial biology COMET Suite includes a wide range of tools and applications, such as the SPYRE™ Protein Detection Reagents and HORIZON™ Image Analysis Software.
Its best-in-class same-section hyperplex multiomics application leverages RNAscope™ HiPlex RNA technology and the universal multiplex sequential immunofluorescence (seqIF™) application with off-the-shelf antibodies.

Discover the COMET Suite

Customer Success Stories

Ruchi Komal PhD, Research Fellow
SLCR, National Institute of Mental Health, NIH

RNAscope spatial analysis greatly improves our research by offering high-resolution visualization of gene expression within the SCN... validating discoveries from single-cell data, identifying rare cell populations, and facilitating gene co-expression analysis in situ.

Cheryl Stoddart PhD Ekaterina Maidji

The identification and anatomic location of HIV-infected cells and the effects of tissue environment on virus replication and viral gene expression are all critical for evaluating the pathogenesis of HIV infection and for developing cure strategies to eliminate HIV reservoirs. RNAscope in situ hybridization (ISH) has enabled us to visualize and quantify HIV RNA with single-copy resolution. For work supported by a Federal Contract with NIAID, NIH, we are using this state-of-the-art ISH technology in combination with immunohistochemistry to characterize the tissue and cellular compartments where the virus resides in HIV-infected humanized mice.

Rodrigo Romero PhD,
Memorial Sloan Kettering Cancer Center

The COMET allows our lab to perform any stain we want on the fly, while simultaneously creating a protocol that is easily transferrable to other members of the lab or community. Before, our research might have been limited by cost or time. With the COMET, we can identify markers that are present within established single cell datasets, and rapidly optimize a staining protocol to identify that specific marker across preclinical or clinical samples.

Denis Schapiro PhD,
Heidelberg University Hospital

The Lunaphore COMET™ system has enabled us to perform highly-multiplexed imaging of entire cross sections of mouse hearts with sub-cellular resolution. The flexible panel design accelerated antibody validation and measurements so that we can already perform spatial analysis of the heart at scale.

Breakthrough Spatial Technologies Revolutionizing Healthcare Research

From low-plex chromogenic to high-plex fluorescent assays, our scalable platforms and fully automated workflows bring unmatched performance and flexibility to scientists.

Visualize any protein and RNA target on the same section to reveal new insights in cell phenotype and functions with confidence using RNAscope Detection Systems, proven Bio-Techne antibodies, and the COMET platform.
Reveal transcriptomic insights in spatial context with RNAscope in situ Hybridization, enhancing your ability to study and interpret complex biological systems.
Leveraging the COMET Suite, extract spatial proteomic and multiomic data and transform any assay into multiplex spatial biology through a streamlined and easily integrated process, all in one seamless platform.