Mandi

Name: Mandi
Brand: Tocris Bioscience
SKU: 7681

Tocris Bioscience, part of Bio-Techne | Catalog # 7681

Citations (1)

COA / SDS

Highly efficient chemical inducer of proximity (CIP)

Key Product Details

Description:	Highly efficient chemical inducer of proximity (CIP)
Chemical Name:	4-Chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-α-(2-propyn-1-yloxy)benzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	411.88

View Full Technical Details for Mandi

Technical Data
Citations

Biological Activity for Mandi

Mandi is a chemical inducer of proximity (CIP) in vivo and in vitro (EC₅₀ = 0.43 μM in a luciferase gene expression assay). Mandi induces complex formation between PYR1^Mandi, a mutant of Abscisic Acid (Cat. No. 6554) receptor PYR1, and Abscisic Acid insensitive (ABI). Mandi may be used to induce protein colocalization and interaction. It is non-toxic, orthogonal to mammalian processes and other CIPs, and highly cell permeable.

Technical Data for Mandi

M. Wt	411.88
Formula	C₂₃H₂₂ClNO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	374726-62-2
PubChem ID	11292824
InChi Key	KWLVWJPJKJMCSH-UHFFFAOYSA-N
Smiles	C#CCOC(C=CC(CCNC(C(C1=CC=C(C=C1)Cl)OCC#C)=O)=C2)=C2OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mandi

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.19	100

Preparing Stock Solutions for Mandi

The following data is based on the product molecular weight 411.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.14 mL	24.28 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for Mandi

References are publications that support the biological activity of the product.

Park An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity. Nat.Chem.Biol. 2023 PMID: 37872402
Ziegler Mandipropamid as a chemical inducer of proximity for in vivo applications. Nat.Chem.Biol. 2022 PMID: 34934192