2-Hydroxypropyl-β-cyclodextrin

Name: 2-Hydroxypropyl- β -cyclodextrin
Brand: Tocris Bioscience
SKU: 0708

Tocris Bioscience, part of Bio-Techne | Catalog # 0708

Citations (8)

COA / SDS

Solubilization agent

Key Product Details

Description:	Solubilization agent
Alternative Names:	HBC,Hydroxypropyl-β-cyclodextrin
Molecular Weight:	1400

View Full Technical Details for 2-Hydroxypropyl-β-cyclodextrin

Technical Data
Citations

Biological Activity

The most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC.

Technical Data

M. Wt	1400
Formula	(C₆H₉O₅)₇(C₃H₇O)n
Storage	Store at RT
CAS Number	128446-35-5
PubChem ID	44134771
InChi Key	BZRWCHBEBFPRGF-UHFFFAOYSA-N
Smiles	O[C@@H]1[C@H]8C(COCC(C)O)O[C@H](O[C@H](C(COCC(C)O)O[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O[C@H](C(COCC(C)O)O[C@H](O[C@@H]5C(O)C(O)[C@H](O[C@@H]6C(O)C(O)[C@H](O[C@H](C(COCC(C)O)O[C@H](O8)[C@H]7O)[C@H]7O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)[C@H]4O)[C@@H]4O)OC3COCC(C)O)[C@H]2O)[C@H]2O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	140	100

Preparing Stock Solutions

The following data is based on the product molecular weight 1400.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.71 mL	3.57 mL	7.14 mL
5 mM	0.14 mL	0.71 mL	1.43 mL
10 mM	0.07 mL	0.36 mL	0.71 mL
50 mM	0.01 mL	0.07 mL	0.14 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Pitha Hydroxypropyl-β-cyclodextrin: preparation and characterisation; effects on solubility of drugs. Int.J.Pharmacol.
Frijlink The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm.Res. 1991 PMID: 2052529