ZZL 7

Name: ZZL 7
Brand: Tocris Bioscience
SKU: 7898

Tocris Bioscience, part of Bio-Techne | Catalog # 7898

COA / SDS

Inhibitor of SERT and nNOS interaction

Key Product Details

Description:	Inhibitor of SERT and nNOS interaction
Chemical Name:	N-Acetyl-L-alanyl-L-valine methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	244.29

View Full Technical Details for ZZL 7

Technical Data
Citations

Biological Activity for ZZL 7

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), reduces extracellular 5-HT concentration and downregulates 5-HT_1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 readily crosses the blood-brain barrier.

Technical Data for ZZL 7

M. Wt	244.29
Formula	C₁₁H₂₀N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	99141-91-0
PubChem ID	166176924
InChi Key	RHDUVXUSBMPQOK-CBAPKCEASA-N
Smiles	CC(N[C@@H](C)C(N[C@@H](C(C)C)C(OC)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZZL 7

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	24.43	100
	DMSO	24.43	100

Preparing Stock Solutions for ZZL 7

The following data is based on the product molecular weight 244.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.09 mL	20.47 mL	40.93 mL
5 mM	0.82 mL	4.09 mL	8.19 mL
10 mM	0.41 mL	2.05 mL	4.09 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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References for ZZL 7

References are publications that support the biological activity of the product.

Sun Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science 2022 PMID: 36302033