Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na⁺ and T-type Ca²⁺ channels, stimulates BK_Ca channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Product Specifications

Molecular Weight

212.22

Formula

C₈H₈N₂O₃S

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

1,2-Benzisoxazole-3-methanesulfonamide

CAS Number

68291-97-4

PubChem ID

5734

InChI Key

UBQNRHZMVUUOMG-UHFFFAOYSA-N

SMILES

NS(=O)(=O)CC1=NOC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.12	10
	DMSO	21.22	100

Preparing Stock Solutions for Zonisamide

The following data is based on the product molecular weight 212.22

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.71 mL	23.56 mL	47.12 mL
5 mM	0.94 mL	4.71 mL	9.42 mL
10 mM	0.47 mL	2.36 mL	4.71 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Huang Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17255467
Sobieszek Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 2003 PMID: 14704463
Gluck Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 2004 PMID: 15168218
Tokumaru In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res. 2000 PMID: 11055748

Zonisamide

Tocris Bioscience, part of Bio-Techne | Catalog # 2625

Key Product Details

Description

Alternative Names

View all Other Channel Modulator Compounds »

Product Description