Zoniporide dihydrochloride

Name: Zoniporide dihydrochloride
Brand: Tocris Bioscience
SKU: 2727

Tocris Bioscience, part of Bio-Techne | Catalog # 2727

Citations (2)

COA / SDS

Selective NHE1 inhibitor

Key Product Details

Description:	Selective NHE1 inhibitor
Alternative Names:	CP 597396
Chemical Name:	[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	393.27

View Full Technical Details for Zoniporide dihydrochloride

Technical Data
Citations

Biological Activity for Zoniporide dihydrochloride

Zoniporide dihydrochloride is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (K_i values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent ²²Na⁺ uptake in vitro (IC₅₀ = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC₅₀ = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for Zoniporide dihydrochloride

Zoniporide dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Zoniporide dihydrochloride

M. Wt	393.27
Formula	C₁₇H₁₆N₆O.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	241799-10-0
PubChem ID	22267855
InChi Key	ARZNPJAGKWHEHT-UHFFFAOYSA-N
Smiles	O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zoniporide dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.93	10
	DMSO	39.33	100

Preparing Stock Solutions for Zoniporide dihydrochloride

The following data is based on the product molecular weight 393.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.71 mL	25.43 mL
5 mM	0.51 mL	2.54 mL	5.09 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for Zoniporide dihydrochloride

References are publications that support the biological activity of the product.

Marala Zoniporide: a potent and highly selective inhibitor of human Na⁺/H⁺ exchanger-1. Eur.J.Pharmacol. 2002 PMID: 12223226
Clements-Jewery Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 2004 PMID: 15037516
Knight A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 2001 PMID: 11259552