Zoniporide dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2727
Selective NHE1 inhibitor
Key Product Details
Description
Selective NHE1 inhibitor
Alternative Names
CP 597396
Product Description
Zoniporide dihydrochloride is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.Licensing Information
Sold for research purposes under agreement from Pfizer IncProduct Specifications
Molecular Weight
393.27
Formula
C17H16N6O.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride
CAS Number
241799-10-0
PubChem ID
22267855
InChI Key
ARZNPJAGKWHEHT-UHFFFAOYSA-N
SMILES
O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.93 | 10 | |
| DMSO | 39.33 | 100 |
Preparing Stock Solutions
for Zoniporide dihydrochloride
The following data is based on the product molecular weight 393.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.71 mL | 25.43 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Marala Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1. Eur.J.Pharmacol. 2002 PMID: 12223226
- Clements-Jewery Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 2004 PMID: 15037516
- Knight A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 2001 PMID: 11259552
Product Specific Notices for Zoniporide dihydrochloride
For research use only
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