ZK 756326

Tocris Bioscience, part of Bio-Techne | Catalog # 2565

Selective, non-peptide CCR8 agonist
Discontinued Product
2565 has been discontinued. View all Chemokine Receptor Agonists products.

Key Product Details

Description

Selective, non-peptide CCR8 agonist

View all Chemokine Receptor Agonists »

Product Description

ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.

Product Specifications

Molecular Weight

429.38

Formula

C21H28N2O3.2HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride

CAS Number

1780259-94-0

PubChem ID

56972201

InChI Key

MPACCEKWFGWZHS-UHFFFAOYSA-N

SMILES

OCCOCCN(CC3)CCN3CC1=CC=CC(OC2=CC=CC=C2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 42.94 100

Preparing Stock Solutions for ZK 756326

The following data is based on the product molecular weight 429.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.29 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ZK 756326

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZK 756326

For research use only

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