ZK 164015

Name: ZK 164015
Brand: Tocris Bioscience
SKU: 2183

Tocris Bioscience, part of Bio-Techne | Catalog # 2183

COA / SDS

Potent estrogen receptor antagonist

Discontinued Product

2183 has been discontinued. View all Estrogen and Related Receptor Antagonists products.

Key Product Details

Description:	Potent estrogen receptor antagonist
Chemical Name:	2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decyl]-1H-indol-5-ol
Purity:	≥99% (HPLC)
Molecular Weight:	513.73

View Full Technical Details for ZK 164015

Technical Data
Citations

Biological Activity for ZK 164015

ZK 164015 is a potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC₅₀ = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC₅₀ ~ 1 nM).

Technical Data for ZK 164015

M. Wt	513.73
Formula	C₃₀H₄₃NO₄S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	177583-70-9
PubChem ID	9806489
InChi Key	LYJSJVYJLZOMCD-UHFFFAOYSA-N
Smiles	CCCCCS(=O)(=O)CCCCCCCCCCN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ZK 164015

References are publications that support the biological activity of the product.

Walter Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg.Med.Chem.Lett. 2004 PMID: 15324884
Biberger and von Angerer 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity. J.Steroid Biochem.Molec.Biol.
Liu The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system. Biol.Chem. 1999 PMID: 10614829

ZK 164015

Tocris Bioscience, part of Bio-Techne | Catalog # 2183

Key Product Details

Biological Activity for ZK 164015

Technical Data for ZK 164015

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ZK 164015

Product Documents for ZK 164015

COA

Certificate of Analysis

SDS

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