Zaprinast

Name: Zaprinast
Brand: Tocris Bioscience
SKU: 0947

Tocris Bioscience, part of Bio-Techne | Catalog # 0947

Citations (57)

COA / SDS

GPR35 agonist

Key Product Details

Description:	GPR35 agonist
Chemical Name:	2-(2-Propyloxyphenyl)-8-azapurin-6-one
Purity:	≥98% (HPLC)
Molecular Weight:	271.28

View Full Technical Details for Zaprinast

Technical Data
Citations

Biological Activity for Zaprinast

Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Compound Libraries for Zaprinast

Zaprinast is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Zaprinast

M. Wt	271.28
Formula	C₁₃H₁₃N₅O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	37762-06-4
PubChem ID	5722
InChi Key	REZGGXNDEMKIQB-UHFFFAOYSA-N
Smiles	CCCOC1=C(C=CC=C1)C1=NC2=C(NN=N2)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zaprinast

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Zaprinast

The following data is based on the product molecular weight 271.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.43 mL	36.86 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Zaprinast

References are publications that support the biological activity of the product.

Christensen and Torphy Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem.
Soderling Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 1998 PMID: 9624145
Taniguchi Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 2006 PMID: 16934253
Lugnier Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 2006 PMID: 16102838