ZAP 180013
Tocris Bioscience, part of Bio-Techne | Catalog # 6821
Zap70 inhibitor; inhibits interaction with ITAMs
Key Product Details
Description
Zap70 inhibitor; inhibits interaction with ITAMs
Product Description
ZAP 180013 is a zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.Product Specifications
Molecular Weight
454.32
Formula
C19H17Cl2N3O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide
CAS Number
873080-25-2
PubChem ID
2988718
InChI Key
GTWKIPDKVRLUKN-UHFFFAOYSA-N
SMILES
O=C(N(CC1=CC=C(Cl)C=C1)CC2=CC=CO2)C3=NC(S(=O)(CC)=O)=NC=C3Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.43 | 100 |
Preparing Stock Solutions
for ZAP 180013
The following data is based on the product molecular weight 454.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 11.01 mL | 22.01 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.40 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Visperas Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen. SLAS.Discov. 2017 PMID: 27932698
Product Specific Notices for ZAP 180013
For research use only
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