ZAP 180013

Name: ZAP 180013
Brand: Tocris Bioscience
SKU: 6821

Tocris Bioscience, part of Bio-Techne | Catalog # 6821

Citations (2)

COA / SDS

Zap70 inhibitor; inhibits interaction with ITAMs

Key Product Details

Description:	Zap70 inhibitor; inhibits interaction with ITAMs
Chemical Name:	5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	454.32

View Full Technical Details for ZAP 180013

Technical Data
Citations

Biological Activity for ZAP 180013

ZAP 180013 is a zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC₅₀ = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.

Compound Libraries for ZAP 180013

ZAP 180013 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for ZAP 180013

M. Wt	454.32
Formula	C₁₉H₁₇Cl₂N₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	873080-25-2
PubChem ID	2988718
InChi Key	GTWKIPDKVRLUKN-UHFFFAOYSA-N
Smiles	O=C(N(CC1=CC=C(Cl)C=C1)CC2=CC=CO2)C3=NC(S(=O)(CC)=O)=NC=C3Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZAP 180013

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.43	100

Preparing Stock Solutions for ZAP 180013

The following data is based on the product molecular weight 454.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	11.01 mL	22.01 mL
5 mM	0.44 mL	2.20 mL	4.40 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for ZAP 180013

References are publications that support the biological activity of the product.

Visperas Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen. SLAS.Discov. 2017 PMID: 27932698