Zanamivir

Name: Zanamivir
Brand: Tocris Bioscience
SKU: 7187

Tocris Bioscience, part of Bio-Techne | Catalog # 7187

COA / SDS

Potent influenza virus neuraminidase inhibitor

Key Product Details

Description:	Potent influenza virus neuraminidase inhibitor
Chemical Name:	5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galactonon-2-enonic acid-glycero-D-galactonon-2-enonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	332.31

View Full Technical Details for Zanamivir

Technical Data
Citations

Biological Activity for Zanamivir

Zanamivir is an influenza viral neuraminidase inhibitor (IC₅₀ values are 0.95 nM and 2.7 nM for influenza A and B, respectively). Inhibits neuraminidase, preventing the cleavage of sialic acid on the cell receptors, and release of the newly formed virions.

Technical Data for Zanamivir

M. Wt	332.31
Formula	C₁₂H₂₀N₄O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	139110-80-8
PubChem ID	60855
InChi Key	ARAIBEBZBOPLMB-UFGQHTETSA-N
Smiles	[H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zanamivir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.66	5

Preparing Stock Solutions for Zanamivir

The following data is based on the product molecular weight 332.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	60.18 mL	300.92 mL	601.85 mL
0.25 mM	12.04 mL	60.18 mL	120.37 mL
0.5 mM	6.02 mL	30.09 mL	60.18 mL
2.5 mM	1.20 mL	6.02 mL	12.04 mL

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Reconstitution Calculator

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References for Zanamivir

References are publications that support the biological activity of the product.

Elliott Zanamivir: from drug design to the clinic. Philos.Trans.R.Soc.Lond.B.Biol.Sci. 2001 PMID: 11779388
McKimm-Breschkin Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir.Med. 2005 PMID: 15813662
Gubareva Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob.Agents Chemother. 2001 PMID: 11709315