Z-DEVD-FMK Caspase-3 Inhibitor

Name: Z-DEVD-FMK Caspase-3 Inhibitor
Brand: Tocris Bioscience
SKU: 8009

Tocris Bioscience, part of Bio-Techne | Catalog # 8009

Citations (1)

COA / SDS

Caspase-3 Inhibitor

Key Product Details

Description:	Caspase-3 Inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	668.67

View Full Technical Details for Z-DEVD-FMK Caspase-3 Inhibitor

Technical Data
Citations

Biological Activity for Z-DEVD-FMK Caspase-3 Inhibitor

Z-DEVD-FMK Caspase-3 Inhibitor is a cell-permeable, irreversible inhibitor of caspase-3/CPP32. It inhibits tumor cell apoptosis. In vivo, it has a neuroprotective effect in rat hippocampus following seizures. It also significantly reduces post-traumatic apoptosis, and improved neurological recovery, before and after induced traumatic brain injury in rat.

Technical Data for Z-DEVD-FMK Caspase-3 Inhibitor

M. Wt	668.67
Formula	C₃₀H₄₁FN₄O₁₂
Single Letter Sequence	DEVD (Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = DL-Asp(OMe)-fluoromethylketone)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	634911-78-7
InChi Key	GBJVAVGBSGRRKN-OXMHKTTFSA-N
Smiles	[H]N(C(OCC1=CC=CC=C1)=O)[C@H](C(N[C@H](C(N[C@H](C(NC(C(CF)=O)CC(OC)=O)=O)C(C)C)=O)CCC(OC)=O)=O)CC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Z-DEVD-FMK Caspase-3 Inhibitor

Solubility

Soluble to 1mg/ml in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Z-DEVD-FMK Caspase-3 Inhibitor

References are publications that support the biological activity of the product.

Yakovlev Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J.Neurosci. 1997 PMID: 9295387
Henshall Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 2000 PMID: 10693954
Kugawa Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 2000 PMID: 10963298
Brocksted Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 1998 PMID: 9774422