Yoda 2
Tocris Bioscience, part of Bio-Techne | Catalog # 8051
Piezo1 channel activator
Product Description
Yoda 2 is a selective Piezo1 channel activator (EC50 values are 150 nM and 1.14 μM in mPiezo1 and HUVEC cells respectively). Increases Ca2+ signaling 2.8 fold in hPIEZO-TREx and 1.2 fold in mPIEZO1-TREx, compared to Yoda 1 (Cat. No. 5586). Induces concentration-dependent relaxation of mouse portal vein (EC50 = 1.2 μM). Suitable for use in vivo and in vitro.Product Specifications
Molecular Weight
435.38
Formula
C16H9Cl2N2O2S2K
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
Potassium 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate
CAS Number
3081450-95-2
InChI Key
OQEIWUHZUPFUQU-UHFFFAOYSA-M
SMILES
O=C([O-])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1.[K+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.54 | 100 | |
| DMSO | 21.77 | 50 |
Preparing Stock Solutions
for Yoda 2
The following data is based on the product molecular weight 435.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.48 mL | 22.97 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.59 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Parsonage Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. Br.J.Pharmacology 2023 PMID: 36457143
Product Specific Notices for Yoda 2
For research use only
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