Yhhu 3792

Name: Yhhu 3792
Brand: Tocris Bioscience
SKU: 6599

Tocris Bioscience, part of Bio-Techne | Catalog # 6599

Citations (8)

COA / SDS

Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo

Key Product Details

Description:	Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo
Chemical Name:	5-(3-Methoxyphenoxy)-N²-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	436.93

View Full Technical Details for Yhhu 3792

Technical Data
Citations

Biological Activity for Yhhu 3792

Yhhu 3792 is a notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes5. Expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after chronic administration in mice. Increases the spatial and episodic memory in mice.

Compound Libraries for Yhhu 3792

Yhhu 3792 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Yhhu 3792

M. Wt	436.93
Formula	C₂₄H₂₄N₄O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2624336-93-0
InChi Key	WNNJMAWCEOKXEJ-UHFFFAOYSA-N
Smiles	COC1=CC=CC(OC2=CC=CC3=C2C(N)=NC(NC4=CC=C(C(C)C)C=C4)=N3)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Yhhu 3792

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.69	100

Preparing Stock Solutions for Yhhu 3792

The following data is based on the product molecular weight 436.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.44 mL	22.89 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.14 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Yhhu 3792

References are publications that support the biological activity of the product.

Lu A novel 2-phenylamino-quinazoline-based compound expands the neural stem cell pool and promotes the hippocampal neurogenesis and the cognitive ability of adult mice. Stem Cells 2018 PMID: 29726088