Y 134
Tocris Bioscience, part of Bio-Techne | Catalog # 2676
Selective estrogen receptor modulator (SERM), selective for ERα
Key Product Details
Description
Selective estrogen receptor modulator (SERM), selective for ERα
Product Description
Y 134 is a selective estrogen receptor modulator (SERM) that displays selectivity for ERα over ERβ (Ki values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.Product Specifications
Molecular Weight
472.60
Formula
C28H28N2O3S
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone
CAS Number
849662-80-2
PubChem ID
11784736
InChI Key
LQEOPHGPHCWOAC-UHFFFAOYSA-N
SMILES
CC(C)N1CCN(CC1)C1=CC=C(C=C1)C(=O)C1=C(SC2=CC(O)=CC=C12)C1=CC=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.26 | 100 | |
| Ethanol | 47.26 | 100 |
Preparing Stock Solutions
for Y 134
The following data is based on the product molecular weight 472.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.58 mL | 21.16 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ning Biological activities of a novel selective oestrogen receptor modulator derived from ralox. (Y134). Br.J.Pharmacol. 2007 PMID: 17115070
- Yang Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo. Bioorg.Med.Chem.Lett. 2005 PMID: 15713417
Product Specific Notices for Y 134
For research use only
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