XIE62-1004

Product Description

XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro. Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.

Solubility

Preparing Stock Solutions for XIE62-1004

The following data is based on the product molecular weight 399.91

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.50 mL	62.51 mL	125.03 mL
1 mM	2.50 mL	12.50 mL	25.01 mL
2 mM	1.25 mL	6.25 mL	12.50 mL
10 mM	0.25 mL	1.25 mL	2.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cha-Molstad p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat.Commun. 2017 PMID: 28740232
• Zhang ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat.Commun. 2018 PMID: 30349045