Xanomeline oxalate

Tocris Bioscience, part of Bio-Techne | Catalog # 3569

Functionally biased muscarinic M4 receptor agonist
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Key Product Details

Description

Functionally biased muscarinic M4 receptor agonist

View all mAChR M4 Receptor Agonists »

Product Description

Xanomeline oxalate is a functionally biased muscarinic M4 receptor agonist (EC50 values are 14.1 nM, 30.9 nM, 1700 nM, 1800 nM and 8500 nM at M4, M1, M2, M5 and M3 receptors respectively. Binds with similar affinity to all muscarinic acetylcholine receptors (pKi 6.7-7.7) but displays higher efficacy and efficacy-driven selectivity at M4 receptors. Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

Product Specifications

Molecular Weight

371.46

Formula

C14H23N3OS.C2H2O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate

CAS Number

141064-23-5

PubChem ID

18920248

InChI Key

ZJOUESNWCLASJP-UHFFFAOYSA-N

SMILES

CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.71 10 with gentle warming
DMSO 37.15 100

Preparing Stock Solutions for Xanomeline oxalate

The following data is based on the product molecular weight 371.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Xanomeline oxalate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Xanomeline oxalate

For research use only

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