XAC
Tocris Bioscience, part of Bio-Techne | Catalog # 3200
Adenosine receptor antagonist
Key Product Details
Description
Adenosine receptor antagonist
Alternative Names
Xanthine amine congener
Product Description
XAC is an adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.Product Specifications
Molecular Weight
501.41
Formula
C21H28N6O4.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride
CAS Number
1962928-23-9
PubChem ID
121513846
InChI Key
KGNTWECSNGWFKE-UHFFFAOYSA-N
SMILES
O=C1N(CCC)C(C(NC(C3=CC=C(OCC(NCCN)=O)C=C3)=N2)=C2N1CCC)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.14 | 100 |
Preparing Stock Solutions
for XAC
The following data is based on the product molecular weight 501.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.97 mL | 19.94 mL |
| 5 mM | 0.40 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.20 mL | 1.00 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sawmiller Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations. Cardiovasc.Res. 1994 PMID: 8025903
- Wei beta and Grisshammer Purification and characterization of the human adenosine A2A receptor functionally expressed in Escherichia coli. Eur.J.Biochem. 2002 PMID: 11784301
- Morgan Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC) Life Sci. 1989 PMID: 2779359
Product Specific Notices for XAC
For research use only
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