WZB 117
Tocris Bioscience, part of Bio-Techne | Catalog # 6143
GLUT inhibitor
Product Description
WZB 117 is a GLUT inhibitor (Ki(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-methylglucose (3MG) uptake in vitro (Ki = 6 μM). Suppresses tumor growth in a nude mouse model.Product Specifications
Molecular Weight
368.31
Formula
C20H13FO6
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
CAS Number
1223397-11-2
PubChem ID
46830365
InChI Key
FRSWCCBXIHFKKY-UHFFFAOYSA-N
SMILES
OC1=CC=CC(C(OC2=C(C(F)=CC=C2)OC(C3=CC(O)=CC=C3)=O)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.83 | 100 | |
| Ethanol | 36.83 | 100 |
Preparing Stock Solutions
for WZB 117
The following data is based on the product molecular weight 368.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.72 mL | 13.58 mL | 27.15 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.43 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.72 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol.Cancer Ther. 2012 PMID: 22689530
- Koch Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget 2015 PMID: 26293674
- Ojelabi WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site. J.Biol.Chem. 2016 PMID: 27836974
Product Specific Notices for WZB 117
For research use only
Loading...
Loading...