WKYMVm

Tocris Bioscience, part of Bio-Techne | Catalog # 1800

COA / SDS

FPR1, FPR2 and FPR3 receptor agonist

Key Product Details

Description:	FPR1, FPR2 and FPR3 receptor agonist
Alternative Names:	Leukocyte chemoattractant peptide
Purity:	≥95% (HPLC)
Molecular Weight:	856.11

View Full Technical Details for WKYMVm

Technical Data
Citations

Biological Activity for WKYMVm

WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC₅₀ = 75 pM) and FPR3 (EC₅₀ = 3 nM), expressed on immune cells. Induces Ca²⁺ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.

Technical Data for WKYMVm

M. Wt	856.11
Formula	C₄₁H₆₁N₉O₇S₂
Single Letter Sequence	WKYMVM (Modifications: Met-6 = D-Met & C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	187986-17-0
PubChem ID	457933
InChi Key	FMBGOORJEKQQLG-JUZZZACGSA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WKYMVm

Solubility

Soluble to 2mg/ml in water

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References for WKYMVm

References are publications that support the biological activity of the product.

Christophe The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH₂ specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 2001 PMID: 11285256
Le Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 1999 PMID: 10586077
Bae The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 2002 PMID: 11818455