WAY 252623
Tocris Bioscience, part of Bio-Techne | Catalog # 5951
Potent LXR agonist
Product Description
WAY 252623 is a potent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
422.78
Formula
C21H12ClF5N2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
CAS Number
875787-07-8
PubChem ID
16734800
InChI Key
KYWWJENKIMRJBI-UHFFFAOYSA-N
SMILES
ClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.28 | 100 | |
| Ethanol | 42.28 | 100 |
Preparing Stock Solutions
for WAY 252623
The following data is based on the product molecular weight 422.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.83 mL | 23.65 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Quinet LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 2009 PMID: 19318684
- DiBlasio-Smith Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 2008 PMID: 18925943
Product Specific Notices for WAY 252623
For research use only
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