WAY 181187 oxalate
Tocris Bioscience, part of Bio-Techne | Catalog # 5589
High affinity and selective 5-HT6 agonist
Key Product Details
Description
High affinity and selective 5-HT6 agonist
Product Description
WAY 181187 oxalate is a high affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.Licensing Information
Sold for research purposes under agreement from Pfizer IncProduct Specifications
Molecular Weight
470.91
Formula
C15H13ClN4O2S2.C2H2O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate
CAS Number
1883548-85-3
PubChem ID
121513871
InChI Key
KAFVDFYVWBASDD-UHFFFAOYSA-N
SMILES
NCCC2=CN(S(C3=C(Cl)N=C4N3C=CS4)(=O)=O)C1=CC=CC=C12.O=C(O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.09 | 100 |
Preparing Stock Solutions
for WAY 181187 oxalate
The following data is based on the product molecular weight 470.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.62 mL | 21.24 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cole Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 2007 PMID: 17948978
- Brouard Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 2015 PMID: 25837696
Product Specific Notices for WAY 181187 oxalate
For research use only
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