WAY 100635 maleate

Name: WAY 100635 maleate
Brand: Tocris Bioscience
SKU: 4380
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4380

(1)

Citations (34)

COA / SDS

Potent 5-HT1A antagonist; also D4 agonist

Key Product Details

Description:	Potent 5-HT_1A antagonist; also D₄ agonist
Chemical Name:	N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
Purity:	≥98% (HPLC)
Molecular Weight:	538.64

View Full Technical Details for WAY 100635 maleate

Technical Data
Citations / Reviews (1)

Biological Activity for WAY 100635 maleate

WAY 100635 maleate is a potent, silent antagonist of 5-HT_1A receptors (IC₅₀ = 2.2 nM; K_i = 0.84 nM for rat 5-HT_1A receptors). Displays 100-fold selectivity for 5-HT_1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D₄ receptors.

Technical Data for WAY 100635 maleate

M. Wt	538.64
Formula	C₂₅H₃₄N₄O₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1092679-51-0
PubChem ID	11957721
InChi Key	XIGAHNVCEFUYOV-BTJKTKAUSA-N
Smiles	O=C(C4CCCCC4)N(C3=NC=CC=C3)CCN(CC2)CCN2C1=C(OC)C=CC=C1.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 100635 maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	13.47	25

Preparing Stock Solutions for WAY 100635 maleate

The following data is based on the product molecular weight 538.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.43 mL	37.13 mL	74.26 mL
1.25 mM	1.49 mL	7.43 mL	14.85 mL
2.5 mM	0.74 mL	3.71 mL	7.43 mL
12.5 mM	0.15 mL	0.74 mL	1.49 mL

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References for WAY 100635 maleate

References are publications that support the biological activity of the product.

Chemel WAY-100635 is a potent DA D₄ receptor agonist. Psychopharmacology (Berl). 2006 PMID: 16915381
Zhuang Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT_1A ligand. J.Med.Chem. 1994 PMID: 8182697
Forster A pharmacological profile of the selective silent 5-HT_1A receptor antagonist, WAY-100635. Eur.J.Pharmacol. 1995 PMID: 8566121
Mensonides-Harsema Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635. J.Med.Chem. 2000 PMID: 10669570