W 54011
Tocris Bioscience, part of Bio-Techne | Catalog # 5455
High affinity C5a receptor antagonist
Key Product Details
Description
High affinity C5a receptor antagonist
Product Description
W 54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).Product Specifications
Molecular Weight
493.08
Formula
C30H36N2O2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
CAS Number
405098-33-1
PubChem ID
5311121
InChI Key
UKBJWRMNGCDKNL-UHFFFAOYSA-N
SMILES
CC(C)C1=CC=C(N(CC2=CC=C(N(C)C)C=C2)C(C3C(C=C(OC)C=C4)=C4CCC3)=O)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.65 | 50 |
Preparing Stock Solutions
for W 54011
The following data is based on the product molecular weight 493.08
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.06 mL | 20.28 mL | 40.56 mL |
| 2.5 mM | 0.81 mL | 4.06 mL | 8.11 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Monk Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 2007 PMID: 17603557
- Cho Autocrine effects of tumor-derived complement. Cell Rep. 2014 PMID: 24613353
- Sumichika Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 2002 PMID: 12384495
Product Specific Notices for W 54011
For research use only
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