VU 0467485

Tocris Bioscience, part of Bio-Techne | Catalog # 6932

Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant
Discontinued Product
6932 has been discontinued. View all mAChR M4 Modulators products.

Key Product Details

Description

Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant

View all mAChR M4 Modulators »

Product Description

VU 0467485 is a potent and selective positive allosteric modulator of M4 receptor; potentiates activity of ACh at M4 (EC50 values are 26.6 and 78.8 nM at rat and human M4 receptors, respectively). Exhibits selectivity for M4 over human and rat M1-3, 5, and a panel of 200 other pharmacological targets. Displays efficacy in a rat model of antipsychotic activity. Orally bioavailable and brain penetrant.

Licensing Information

Sold under license from Vanderbilt University.

Product Specifications

Molecular Weight

360.41

Formula

C17H17FN4O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-Amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

CAS Number

1451994-10-7

PubChem ID

89777239

InChI Key

VFNHDIWHQGVWLL-UHFFFAOYSA-N

SMILES

COC1=C(C=C(C=C1)CNC(C2=C(C3=C(C(C)=NN=C3S2)C)N)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.21 20

Preparing Stock Solutions for VU 0467485

The following data is based on the product molecular weight 360.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.87 mL 69.37 mL 138.73 mL
1 mM 2.77 mL 13.87 mL 27.75 mL
2 mM 1.39 mL 6.94 mL 13.87 mL
10 mM 0.28 mL 1.39 mL 2.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VU 0467485

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 0467485

For research use only

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