VU 0285683

Name: VU 0285683
Brand: Tocris Bioscience
SKU: 4381

Tocris Bioscience, part of Bio-Techne | Catalog # 4381

COA / SDS

Negative allosteric modulator of mGlu5 receptors

Discontinued Product

4381 has been discontinued. View all Group I mGluR Modulators products.

Key Product Details

Description:	Negative allosteric modulator of mGlu₅ receptors
Chemical Name:	3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	266.23

View Full Technical Details for VU 0285683

Technical Data
Citations

Biological Activity for VU 0285683

VU 0285683 is a negative allosteric modulator of mGlu₅ receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu₅ (IC₅₀ = 24.4 nM). Selective for mGlu₅ over mGlu₁, mGlu₃ and mGlu₄. Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323).

Technical Data for VU 0285683

M. Wt	266.23
Formula	C₁₄H₇FN₄O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	327056-22-4
PubChem ID	9816778
InChi Key	GELAFISMURFRCA-UHFFFAOYSA-N
Smiles	FC1=CC(C#N)=CC(C2=NC(C3=NC=CC=C3)=NO2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VU 0285683

References are publications that support the biological activity of the product.

Rodriguez Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 2010 PMID: 20923853

VU 0285683

Tocris Bioscience, part of Bio-Techne | Catalog # 4381

Key Product Details

Biological Activity for VU 0285683

Technical Data for VU 0285683

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for VU 0285683

Product Documents for VU 0285683

COA

Certificate of Analysis

SDS

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