VU 0238429

Name: VU 0238429
Brand: Tocris Bioscience
SKU: 3634

Tocris Bioscience, part of Bio-Techne | Catalog # 3634

Citations (3)

COA / SDS

Selective positive allosteric modulator of M5 receptors

Discontinued Product

3634 has been discontinued. View all mAChR M5 Modulators products.

Key Product Details

Description:	Selective positive allosteric modulator of M₅ receptors
Chemical Name:	1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
Purity:	≥97% (HPLC)
Molecular Weight:	351.28

View Full Technical Details for VU 0238429

Technical Data
Citations

Biological Activity for VU 0238429

VU 0238429 is a selective positive allosteric modulator of M₅ receptors (EC₅₀ values are 1.16, >30 and >30 μM at M₅, M₁ and M₃ receptors respectively). Displays no activity at M₂ and M₄ receptors.

Compound Libraries for VU 0238429

VU 0238429 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0238429

M. Wt	351.28
Formula	C₁₇H₁₂F₃NO₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1160247-92-6
PubChem ID	42633508
InChi Key	CKLGZXFOLMHCMC-UHFFFAOYSA-N
Smiles	O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(OC)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VU 0238429

References are publications that support the biological activity of the product.

Bridges Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 2009 PMID: 19438238