VHL-SNAP2-5C

Name: VHL-SNAP2-5C
Brand: Tocris Bioscience
SKU: 8890

Tocris Bioscience, part of Bio-Techne | Catalog # 8890

COA / SDS

Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins

Key Product Details

Description:	Degrader (PROTAC^®) of SNAP-tag™ labeled fusion proteins
Chemical Name:	N¹-(4-(((2-Amino-6-chloropyrimidin-4-yl)oxy)methyl)benzyl)-N⁷-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)heptanediamide
Purity:	≥98% (HPLC)
Molecular Weight:	833.45

View Full Technical Details for VHL-SNAP2-5C

Technical Data
Citations

Biological Activity for VHL-SNAP2-5C

VHL-SNAP2-5C is a Degrader (PROTAC^®) of SNAP-tag™ labeled fusion proteins (D_max = 80% at 1 μM). VHL-SNAP2-5C recruits VHL E3 ligase to induce the degradation of SNAP-fusion proteins.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

SNAP-tag is a trademark of New England BioLabs, Inc.

Technical Data for VHL-SNAP2-5C

M. Wt	833.45
Formula	C₄₂H₅₃ClN₈O₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	RZNBOJVEQRLLQS-WWGNEEHCSA-N
Smiles	CC1=C(SC=N1)C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCC(NCC4=CC=C(COC5=NC(N)=NC(Cl)=C5)C=C4)=O)=O)C(C)(C)C)=O)=O)C)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VHL-SNAP2-5C

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	83.34	100

Preparing Stock Solutions for VHL-SNAP2-5C

The following data is based on the product molecular weight 833.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.20 mL	6.00 mL	12.00 mL
5 mM	0.24 mL	1.20 mL	2.40 mL
10 mM	0.12 mL	0.60 mL	1.20 mL
50 mM	0.02 mL	0.12 mL	0.24 mL

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References for VHL-SNAP2-5C

References are publications that support the biological activity of the product.

Pol Induced degradation of SNAP-fusion proteins. RSC Chem.Biol. 2024 PMID: 39444693