Verteporfin

Name: Verteporfin
Brand: Tocris Bioscience
SKU: 5305
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5305

(2)

Citations (75)

COA / SDS

YAP inhibitor

Key Product Details

Description:	YAP inhibitor
Alternative Names:	Visudyne
Chemical Name:	(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Purity:	≥95% (HPLC)
Molecular Weight:	718.79

View Full Technical Details for Verteporfin

Technical Data
Citations / Reviews (2)

Biological Activity for Verteporfin

Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC₅₀ = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Technical Data for Verteporfin

M. Wt	718.79
Formula	C₄₁H₄₂N₄O₈
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	129497-78-5
PubChem ID	5362420
InChi Key	YHNBVDZVUQFVLS-SKJZPIBWSA-N
Smiles	CC(C(/C=C1N/C([C@@]2(C)C\1=CC=C(C(OC)=O)[C@H]2C(OC)=O)=C\C3=N/C(C(CCC(O)=O)=C3C)=C\4)=N/5)=C(C=C)C5=C\C6=C(C)C(CCC(OC)=O)=C4N6.CC(C(/C=C7N/C([C@@]8(C)C\7=CC=C(C(OC)=O)[C@H]8C(OC)=O)=C\C9=N/C(C(CCC(OC)=O)=C9C)=C\%10)=N/%11)=C(C=C)C%11=C\C%12=C(C)C(CCC(O)=O)=C%10N%12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Verteporfin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	14.38	20

Preparing Stock Solutions for Verteporfin

The following data is based on the product molecular weight 718.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.96 mL	34.78 mL	69.56 mL
1 mM	1.39 mL	6.96 mL	13.91 mL
2 mM	0.70 mL	3.48 mL	6.96 mL
10 mM	0.14 mL	0.70 mL	1.39 mL

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References for Verteporfin

References are publications that support the biological activity of the product.

Brodowska The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 2014 PMID: 24837142
Song Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 2014 PMID: 24906622
Liu-Chittenden Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012 PMID: 22677547