Verdinexor

Name: Verdinexor
Brand: Tocris Bioscience
SKU: 7569

Tocris Bioscience, part of Bio-Techne | Catalog # 7569

COA / SDS

Selective exportin-1 (XPO1/CRM1) inhibitor

Key Product Details

Description:	Selective exportin-1 (XPO1/CRM1) inhibitor
Chemical Name:	(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	442.32

View Full Technical Details for Verdinexor

Technical Data
Citations

Biological Activity for Verdinexor

Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor. It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro, including H1N1, H5N1 and H7N9 (IC₅₀ values in the range 40 - 420 nM range). Verdinexor limits influenza A virus spread in mouse lung in vivo. In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis. It also induces P53 nuclear accumulation and induces G₀/G₁ phase cell cycle arrest by activating P53 function. Verdinexor inhibits tumor growth in in vivo mouse models. Orally bioavailable.

Technical Data for Verdinexor

M. Wt	442.32
Formula	C₁₈H₁₂F₆N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1392136-43-4
PubChem ID	71492799
InChi Key	OPAKEJZFFCECPN-XQRVVYSFSA-N
Smiles	C(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C(NNC3=CC=CC=N3)=O)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Verdinexor

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.23	100
	ethanol	2.21	5

Preparing Stock Solutions for Verdinexor

The following data is based on the product molecular weight 442.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.30 mL	22.61 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for Verdinexor

References are publications that support the biological activity of the product.

Perwitasari Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo J.Virol. 2014 PMID: 24965445
Pan XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor. J.Exp.Clin.Cancer Res. 2021 PMID: 34384466