VER 155008
Tocris Bioscience, part of Bio-Techne | Catalog # 3803
Hsp70 inhibitor
Product Description
VER 155008 is a novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β (IC50 >200 μM for Hsp90β).Product Specifications
Molecular Weight
556.40
Formula
C25H23Cl2N7O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CAS Number
1134156-31-2
PubChem ID
25195348
InChI Key
ZXGGCBQORXDVTE-UMCMBGNQSA-N
SMILES
NC1=NC=NC2=C1N=C(NCC5=CC=C(Cl)C(Cl)=C5)N2[C@@H]3O[C@H](COCC4=CC=C(C#N)C=C4)[C@@H](O)[C@H]3O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.64 | 100 |
Preparing Stock Solutions
for VER 155008
The following data is based on the product molecular weight 556.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.80 mL | 8.99 mL | 17.97 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.59 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.80 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Macias Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J.Med.Chem. 2011 PMID: 21526763
- Williamson Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. J.Med.Chem. 2009 PMID: 19256508
- Massey ATPases as drug targets: insights from heat shock proteins 70 and 90. J.Med.Chem. 2010 PMID: 20608738
- Massey A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother.Pharmacol. 2009 PMID: 20012863
Product Specific Notices for VER 155008
For research use only
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