UVI 3003
Tocris Bioscience, part of Bio-Techne | Catalog # 3303
RXR antagonist
Discontinued Product
3303 has been discontinued.
An alternative/replacement product is available:
3912. View all Retinoid X Receptor Antagonists products.
Product Description
UVI 3003 is a RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.Product Specifications
Molecular Weight
436.58
Formula
C28H36O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
CAS Number
847239-17-2
PubChem ID
44566108
InChI Key
APJSHECCIRQQDV-ZRDIBKRKSA-N
SMILES
CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(OCCCCC)=C2)C(C)(C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.66 | 100 | |
| Ethanol | 43.66 | 100 |
Preparing Stock Solutions
for UVI 3003
The following data is based on the product molecular weight 436.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.45 mL | 22.91 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Santin Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. J.Med.Chem. 2009 PMID: 19408900
- Nahoum Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci.
- Le Maire Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO Rep. 2009 PMID: 19270714
Product Specific Notices for UVI 3003
For research use only
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