uPSEM 817 tartrate

Name: uPSEM 817 tartrate
Brand: Tocris Bioscience
SKU: 6866

Tocris Bioscience, part of Bio-Techne | Catalog # 6866

Citations (9)

COA / SDS

Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

Key Product Details

Description:	Highly potent and selective PSAM⁴-GlyR and PSAM⁴-5-HT₃ chimeric ion channel agonist; brain-penetrant
Chemical Name:	2-Propoxy-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline L-tartrate
Purity:	≥98% (HPLC)
Molecular Weight:	419.43

View Full Technical Details for uPSEM 817 tartrate

Technical Data
Citations

Biological Activity for uPSEM 817 tartrate

uPSEM 817 tartrate is a selective ultrapotent PSEM (uPSEM) agonist for α7^{L131G,Q139L,Y217F}-GlyR (PSAM⁴-GlyR) and PSAM⁴-5-HT₃ chimeric ion channels (EC₅₀ values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM⁴-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM⁴-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg).

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Technical Data for uPSEM 817 tartrate

M. Wt	419.43
Formula	C₁₆H₁₉N₃O.C₄H₆O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2341833-14-3
Smiles	CCCOC1=NC2=C(N=C1)C=C(C3=C2)C4CNCC3C4.O[C@@H](C(O)=O)[C@@H](O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for uPSEM 817 tartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.94	100
	water	8.39	20

Preparing Stock Solutions for uPSEM 817 tartrate

The following data is based on the product molecular weight 419.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for uPSEM 817 tartrate

References are publications that support the biological activity of the product.

Magnus Ultrapotent chemogenetics for research and potential clinical applications. Science 2019 PMID: 30872534