uPSEM 792 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6865
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
Key Product Details
Description
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
Product Description
uPSEM 792 hydrochloride is an ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
Product Specifications
Molecular Weight
277.75
Formula
C14H15N3O.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride
CAS Number
2341841-08-3
InChI Key
CDHPEJUYEXNGCV-UHFFFAOYSA-N
SMILES
O=C1C=NC2=C(C=C3C(C4CNCC3C4)=C2)N1C.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.77 | 100 |
Preparing Stock Solutions
for uPSEM 792 hydrochloride
The following data is based on the product molecular weight 277.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.60 mL | 18.00 mL | 36.00 mL |
| 5 mM | 0.72 mL | 3.60 mL | 7.20 mL |
| 10 mM | 0.36 mL | 1.80 mL | 3.60 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Magnus Ultrapotent chemogenetics for research and potential clinical applications. Science 2019 PMID: 30872534
Product Specific Notices for uPSEM 792 hydrochloride
For research use only
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