UNC 3230
Tocris Bioscience, part of Bio-Techne | Catalog # 5271
Potent and selective PIP5K1C inhibitor; antinociceptive
Key Product Details
Description
Potent and selective PIP5K1C inhibitor; antinociceptive
Product Description
UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.Product Specifications
Molecular Weight
344.43
Formula
C17H20N4O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
CAS Number
1031602-63-7
PubChem ID
46355372
InChI Key
RZCNASHHHSKTGP-UHFFFAOYSA-N
SMILES
O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.44 | 100 |
Preparing Stock Solutions
for UNC 3230
The following data is based on the product molecular weight 344.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.90 mL | 14.52 mL | 29.03 mL |
| 5 mM | 0.58 mL | 2.90 mL | 5.81 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.90 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wright The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 2014 PMID: 24853942
Product Specific Notices for UNC 3230
For research use only
Loading...
Loading...